Kleinfelder: Perchlorate 2008, Seattle

Preliminary Program

Thursday, March 20, 1:00 PM – 4:30 PM
Iodine Modulation of Thyroid Function: Influence of Perchlorate and Other Structurally Related Anions
Chair: Robert Howd

1:00-1:25	Benjamin Blount: Background urinary perchlorate and statistical analysis of its association with serum levels of TSH and T4 in men and women sampled in the National Health and Nutrition Examination Survey (NHANES): The influence of gender and iodine status.
1:25-1:50	Steven Lamm: Statistical analysis of association between urinary perchlorate and serum levels of TSH and T4 in women sampled in the National Health and Nutrition Examination Survey (NHANES): The importance of creatinine adjustment when using spot urines to establish iodine status.
1:50-2:15	Robert Howd: Statistical analysis of association between urinary perchlorate and serum levels of TSH and T4 in women sampled in the National Health and Nutrition Examination Survey (NHANES): Consideration of iodine status, smoking, and thiocyanate.
2:15-2:45	Break.
2:45-3:10	Lewis Braverman: Thyroid function in long-term clinical and occupational exposures to perchlorate: Iodine homeostasis at work.
3:10-3:35	Gay Goodman: New data from the Greer study: The influence of iodine status and gender on the dose-response for perchlorate inhibition of thyroidal iodide uptake in human volunteers.
3:35-4:30	Q&A and audience-interactive discussion.

Friday, March 21, 9:00 AM – 11:15 AM
Fetal and Early-Life Perchlorate Exposures and Outcomes
Chair: Michael Dourson

9:00-9:15	Elizabeth Pearce: Breast milk perchlorate and iodine in a cohort of lactating Boston-area women: Lack of statistical evidence for an effect of perchlorate on breast milk iodine or colostrum iodine.
9:15-9:45	Yona Amitai: Serum T4 levels and neurodevelopmental test scores in Israeli infants from neighborhoods with markedly different perchlorate concentrations in drinking water: Lack of statistical evidence for an effect of drinking-water perchlorate on thyroid function or neurodevelopment.
9:45-10:15	John Gibbs: analysis of association between urinary perchlorate and serum levels of TSH and T4 in mothers and newborns from three Chilean cities with markedly different perchlorate concentrations in drinking water: Does categorization by iodine status affect outcome?
10:15-10:30	Elizabeth Pearce: Statistical analysis of association between urinary perchlorate and serum levels of TSH and free T4 during the first trimester of pregnancy in women from Wales, Italy, Argentina, and California: Lack of evidence for a perchlorate effect, irrespective of iodine status.
10:30-10:45	Q&A.
10:45-11:15	Break.

Friday, March 21, 11:15 AM – 3:30 PM
Natural Perchlorate Sources, New Studies, and Other New Information: Implications for Risk Assessment
Chair: Gay Goodman

11:15-11:45	David Stonestrom: Natural perchlorate in the hydrologic cycle: Review of recent findings.
11:45-12:15	Speakers and session chairs: Moderated discussion of the question: "What can we deduce about the physiological relevance of historical exposures to natural perchlorate?"
12:15-12:30	Gregory Brent (via Web link). Comments on the information presented. Discussion of the question: "Does the new information call for reexamination of the no-effect level and/or uncertainty factor recommended by the NAS/NRC committee?"
12:30-1:45	Catered lunch followed by Q&A and audience-interactive discussion.
1:45-2:00	Break.
2:00-2:30	Speakers and session chairs: Moderated discussion of the question: "What is the role of iodine nutrition in determining perchlorate health risks?”
2:30-3:30	Consensus-building session with audience participation. Moderated discussion of the question: “What does the new information imply for the assessment of perchlorate health risks?
3:30	Adjourn.

PERCHLORATE EXPOSURES, IODINE MODULATION OF EFFECT, AND EPIDEMIOLOGIC ASSOCIATIONS: IMPLICATIONS FOR RISK ASSESSMENT

PERCHLORATE EXPOSURES, IODINE MODULATION OF EFFECT,
AND EPIDEMIOLOGIC ASSOCIATIONS: IMPLICATIONS FOR RISK ASSESSMENT